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POSTPONED, new date t.b.c. Degrading Proteins in the Brain: Can we get there and how can we make it work?

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POSTPONED new date t.b.c.

The Farnaby Group, based in the University of Dundee Centre for Targeted Protein Degradation, are using induced proximity chemistry towards the discovery of new tools and probes for Central Nervous System (CNS) disease understanding and treatment. This is a therapeutic area that has high unmet need and societal burden and where traditional small molecule approaches have had very little recent success for patients. There is a need for improved chemical tools that can help with target validation and understanding and that can probe cellular signalling in new ways. In this talk I will describe development of a direct-to-biology synthesis and screening approach to identify a brain active bifunctional degrader as well as learnings from using multi-Kinase probes as a basis for mechanism agnostic molecular glue discovery.

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