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Collective migration of neural crest cells: a balance of repulsion and attraction

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If you have a question about this talk, please contact Duncan Simpson .

The neural crest is a highly migratory embryonic cell population that gives rise to a huge variety of cells, tissues and organs. A complex network of transcription factors and signaling molecules has been involved in controlling directional migration of neural crest cells. Our aim is to describe this apparently complex cell behavior based on simple cellular rules. We propose that two cellular interactions are sufficient to generate directional migration of neural crest: attraction and repulsion between cells. I will describe the molecular bases of these repulsive and attractive cellular forces and I will discuss a mathematical model that integrates these different kinds of cell interactions to explain the directional collective migration of neural crest cells.

http://www.ucl.ac.uk/cdb/research/mayor

This talk is part of the Physics of Living Matter PLM6 series.

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