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Structural and Biochemical Mechanisms of Synchronous Synaptic Transmission

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SNAR Es fuse cellular membranes, including synaptic vesicles with pre-synaptic plasma membranes to enable synaptic transmission. SNAR Es fuse membranes automatically, so a clamp is needed to prevent premature transmitter release, provided by the protein complexin. Recent studies have established the structural and biochemical mechanism of clamping by complexin involving a co-operative array of partly zippered SNAR Epins whose disolution can explain the syncronicity of transmitter release when the calcium sensor, synaptotagmin, perturbs the array.

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