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Cell specification in the mouse blastocyst inner cell mass: interplay between Nanog, Gata6 and the Fgf signalling pathway.

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If you have a question about this talk, please contact Caroline Newnham .

Our goal is to decipher the mechanisms of cell determination and differentiation in the preimplantation mouse embryo. We are focusing on Primitive Endoderm (PrE) versus Epiblast specification during blastocyst development and in the past years we have shown the interplay between different transcription factors such as Nanog for the Epiblast and Gata6, Sox17, Gata4 and LRP2 for the PrE. We have recently shown that the Fgf4/RTK signalling plays several successive roles in inducing and maintaining PrE specification. These findings have an important impact in stem cell biology, as embryonic stem cells (ES) are derived from blastocysts.

This talk is part of the Genetics Seminar series.

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