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Tracking transmission and evolution of bacterial pathogens with high-throughput genomics.

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If you have a question about this talk, please contact Caroline Newnham .

Host: Frank Jiggins

High-throughput sequencing technologies allow us to perform rapid whole-genome sequencing for hundreds of bacterial strains simultaneously. Using these techniques, we can perform genome sequencing at the population level in order to identify genetic variation for epidemiology, and to look for the signatures of selective pressure and evolutionary change. Data from population-level studies on human pathogens including Staphyloccus aureus, Streptococcus pneumoniae and Vibrio cholerae will be presented showing how we can track transmission routes, and identify the response of these organisms to selective pressures such as antibiotics and vaccines. Advances in rapid sequencing will soon allow the use of these technologies in clinical microbiology for tracking outbreaks and identifying drug resistance, and pilot studies demonstrating the power of these technologies will be presented.

This talk is part of the Genetics Seminar series.

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