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James Wason, MRC Biostatistics
Monday 25 November 2013, 19:15-21:30
Design of multi-arm multi-stage trials
- 👤 Speaker: James Wason, MRC Biostatistics
- 📅 Date & Time: Monday 25 November 2013, 19:15 - 21:30
- 📍 Venue: Department of Applied Mathematics and Theoretical Physics, University of Cambidge
Abstract
In many disease areas there are multiple experimental treatments awaiting testing in clinical trials. Multi-arm trials provide large gains in efficiency over separate randomised trials of each treatment by using a shared control group. Further increases in efficiency can be obtained by introducing interim analyses at which modifications can be made to the proportion of patients allocated to each treatment. Such a design is called a multi-arm multi-stage (MAMS) trial. In this talk I will discuss and compare three classes of MAMS designs that can be used to increase efficiency and ethical properties of a multi-arm trial: group-sequential designs, drop-the-loser designs and adaptive randomisation. I will also discuss some statistical issues that are common to all three.
Series This talk is part of the Cambridge Statistics Discussion Group (CSDG) series.
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