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Deconstructing Greatwall Kinase.

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If you have a question about this talk, please contact Caroline Newnham .

Host: Viji Draviam

Greatwall is a novel mitotic kinase that plays a crucial role in regulating the Cdk counteracting phosphatase PP2A /B55. The precise functions and regulation of Greatwall kinase itself remains to be explored. In my seminar I will report on work in my laboratory on the phosphatases that counteract Greatwall activation. I will also discuss recent efforts in the lab to develop Greatwall as a target in cancer therapy and present unpublished work on a collaboration with the Pearl lab to solve the structure of this kinase and develop an in vitro screen to identify small molecule inhibitors of Greatwall.

This talk is part of the Genetics Seminar series.

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