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From Cells to Seizures: Intrinsic Changes in Sodium Channel Expression and Activity in Epilepsy

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If you have a question about this talk, please contact Tony Jackson .

During the development of epilepsy a number of cellular events are initiated that ultimately lead to an increase in neuronal excitability and the generation of seizures. The resurgent sodium current plays a major role in controlling neuronal excitability. Our studies demonstrate an increase in resurgent sodium channel currents in medial entorhinal cortex (mEC) neurons recorded from a rat model of temporal lobe epilepsy (TLE). Importantly, increases in the resurgent sodium current were detected at an early stage in the development of epilepsy, and before the onset of spontaneous seizures. These studies suggest a critical role for the resurgent current, in part, for establishing the increase in neuronal hyper-excitability associated with epilepsy.

This talk is part of the Cambridge Neuroscience Seminars series.

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