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Chromatin unloading of the replicative DNA helicase during replication and repair

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Researchers studying eukaryotic DNA replication have made extraordinary progress in understanding how the replicative DNA helicase (the ‘CMG’ complex) is recruited to origins in G1, how it is activated in S phase, how it unwinds DNA at the fork, and how its de novo loading in S phase is restricted to prevent re-replication. By comparison, we know almost nothing about what happens when replisomes from adjacent origins meet, including the mechanism of CMG unloading. I will describe a cell-free system from Xenopus eggs that supports synchronous and site-specific replication termination, and what we have learned about CMG unloading using this approach. I will compare and contrast CMG unloading during termination with its unloading during the repair of DNA interstrand cross-links. Our work suggests that the removal of CMG from chromosomes is an active and essential process that is carefully regulated to preserve genome integrity.

This talk is part of the MRC LMB Seminar Series series.

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