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Crick Lecture-The Surprising Chemistry of Non-enzymatic RNA Replication

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The RNA genomes of the first cells are thought to have emerged from the nonenzymatic replication of short RNA strands, which allowed the first ribozymes to evolve, followed by the evolution of ribozyme catalyzed replication. However, no process for the replication of a nucleic acid genome, independent of evolved enzymatic machinery, has yet been described. Dr. Szostak will discuss his laboratory’s recent progress toward the realization of an efficient and accurate system for the chemical replication of RNA . Mechanistic and structural studies have led to new chemical replication systems that are both more prebiotically plausible and more accurate, efficient, and general.

This talk is part of the MRC LMB Seminar Series series.

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