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Paul Bergen: Ordered export of proteins to build a bacterial cell surface nanomachine

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If you have a question about this talk, please contact Charlotte Askew .

Bacteria build rotary nanomachines, called flagella, on their cell surface to move through their environment. Their assembly requires thousands of subunits to be exported across the cell membrane by dedicated type III export machinery. Assembly is biphasic, with subunits for the filament only exported once the rod and hook structures are mature. The order of subunit export is imposed by the FlhB1 export gate and by the molecular ruler, FliK2. I will describe how FliK triggers the export specificity switch by promoting a radical conformational change in FlhB.

This talk is part of the Pathology Valedictory Seminars series.

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