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Using DNA to Program Nanostructure Assembly and Molecular Machinery

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If you have a question about this talk, please contact Lorenzo Di Michele .

Nanofabrication by biomolecular self-assembly can be used to create atomically precise, nanometre-scale structures. The control offered by DNA -self-assembly is spectacular: thousands of oligonucleotides can be designed to form rigid, three-dimensional complexes with defined contours and internal cavities. Each oligonucleotide has a unique sequence which defines its position in these structures, and chemically modified oligonucleotides can be used to position other molecular components. Synthetic nucleic acids can also form programmable dynamic systems which compute and exhibit complex temporal behaviours. I shall survey this rapidly evolving research field and its potential to provide new tools and technologies from biophysics to manufacture to medicine, and describe some of our own work on DNA origami assembly pathways and synthetic molecular machinery, including its use to control covalent chemical synthesis.

This talk is part of the BSS Formal Seminars series.

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