Bioinformatics and other interests
Contact: Sina Beier
6 upcoming talks View 342 archived talks
Cambridge RNA Club - IN PERSON
Remodelling the septin cytoskeleton for cytokinesis in budding yeast
Viruses: from within-host evolution to global pandemics
Cambridge RNA Club - IN PERSON
Cambridge RNA Club - IN PERSON
CANCELLED - Entrenchment and compensation in the evolution of vertebrate gastrulation
Cambridge RNA Club - ONLINE
Cambridge RNA Club - ONLINE
Cambridge RNA Club - IN PERSON
Small RNAs in Epigenetic Inheritance: a lesson from worms
Molecular bases of Shigella virulence and host immune response
Cambridge RNA Club - IN PERSON
Cambridge RNA Club - ONLINE
Cambridge RNA Club - IN PERSON
Cambridge RNA Club - IN PERSON
Cambridge RNA Club - ONLINE
Cambridge RNA Club - IN PERSON
21st century eugenics, scientific racism and the academic community: how science is manipulated to promote political ideology
Cambridge RNA Club - IN PERSON
Embryo-scale reverse genetics at single cell resolution reveals lineage-specific modules underlying cranial development
Cambridge RNA Club - ONLINE
Cambridge RNA Club - ONLINE
Developing AlphaFold 3: Biomolecular structure prediction with AI
Cambridge RNA Club - IN PERSON
CANCELLED - News from the Palaeolithic: ancient genomes and Neandertal-human interactions
How the double helix was really discovered, and what Rosalind Franklin thought about it
Cambridge RNA Club - IN PERSON
What can butterfly hybrid zones tell us about the genomic architecture of species barriers?
Cambridge RNA Club - July session ON ZOOM
Cambridge RNA Club - June session IN PERSON
Cambridge RNA Club - May session IN PERSON
RNA Collaborative Seminar Series special event
Competition for phospholipids drives astrocyte morphogenesis in the CNS
Mutate everything: mapping the energetic and allosteric landscapes of proteins at scale
Cambridge RNA Club - April session ON ZOOM
Cambridge RNA Club - March session IN PERSON
Pathogens through space and time - Lessons from high-throughput screening for ancient pathogen DNA
Building patterning-dependent chromatin states during development.
When the non-coding codes: Mining the microproteome for novel regulators of cancer cell plasticity
Beyond chromatin: Histones as developmental regulators in Drosophila
An ancient ecospecies of Helicobacter pylori found in Indigenous populations and animal adapted lineages
Multiscale synthesis of coupled dynamic gene expression during neural development
Tracking pathogens in space and time: something old, something new
Using synthetic biology to understand pattern-forming gene regulatory networks and their evolution
Challenges and solutions in identifying the genes responsible for local adaptation
Population structure and effects of consanguinity on complex disease in British South Asians
Pathogen phylodynamics: from historical epidemics to contemporary outbreaks
Whodunnit in the genome: Fingerprints of mutagenesis reveal culprits of cancer
Regulation of gene expression during the awakening of the zygotic genome
Connecting Sensory Perception to Longevity in C. elegans
Patterns of purifying selection and adaptive evolution in SARS-CoV-2
Single Cell Technologies : A Bioinformatician’s perspective
Chromosome Architecture: Lifting the Lid on Loop Extrusion
Epigenetics and genome dynamics: what can we learn from ciliates?
Base Editing and Prime Editing: Precise Gene Correction Without Double-Strand DNA Breaks
Why is Wolbachia-induced cytoplasmic incompatibility so common?
A system-wide quantitative map of RNA subcellular re-localization in response to UPR activation
Regulation of physiology via a dietary lipid metabolite.
Using human genetics to define a spectrum of axon vulnerability
Unlocking lncRNA functions using an arrayed CRISPRi screening platform with cellular and molecular phenotyping
Hacking the germline : how paralogs bend the rules of gene expression
A guiding torch at the poles: key roles of the centrosome during asymmetric cell division
Transposons and evolutionary novelties of a symbiotic genome
RNA Length has a non-trivial effect in the stability of biomoelecular condensates formed by RNA-binding proteins
RNA Collaborative Seminar Series special event
Robust tuning of epigenetic memory by resource competition
LINE1 biology and its interactome dynamics after drug treatment
Exploring host-tumour metabolic interactions using Drosophila
Asymmetric cell division and germline immortality
Transparency, reproducibility, and adaptability in data analysis.
Investigating the evolution and development of body plans and body parts in arthropods
Inspecting the early secretory pathway with whole-cell, volumetric FIB-SEM in fed and starved cells
Coping with Mechanical Stress: Tissue dynamics in development and repair
Evolutionary strata on young mating-type chromosomes despite the lack of sexual antagonism.
Telomere-to-Telomere Chromosome Assemblies: New Insights Into Genome Biology & Structure
The origin of mitochondrial DNA mutations: population genetics and disease
Genome regulation by ATP-dependent chromatin remodeling and phase-separation
PP2A-B55 inhibitors Arpp19 and ENSA define the cell cycle program by controlling the temporal pattern of protein phosphorylation
This talk has been cancelled and will be rescheduled for later this year.
Molecular and evolutionary processes generating variation in gene expression
Defining intrinsic determinants of regeneration ability and inability.
Genomic Scope of Adaptive Mutations in the Face of Environmental Challenges
Targeting viral RNA for degradation : the ZAP antiviral system
Deciphering the RNA interactome of SARS-CoV-2
From genomes to genealogies: mapping the history of humans and their genetic variation using ancient and modern genomes
RNA uridyl transferases TUT4/7-mediated control on tumour fitness
Control of global translation by endogenous RNA G-quadruplex structures
Shaping tissues: the role of mechanics across different scales.
Chromosomal evolution in Nematodes, and other adventures on the Tree of Life
[Cancelled] P body phase transitions govern RNA regulation during early Drosophila development
[Cancelled] Replenishing the ends : Structural Mechanism of Human Telomerase
Targeting cancer stem cells while enhancing healthy tissue functions - a novel paradigm for cancer therapies
A bioinformatic strategy for allele-specific RNA expression for distant tomato crosses
This talk has been cancelled
Genomics of speciation and adaptation in the Lake Malawi cichlid fish radiation
Decoding Transcriptional Regulation and Kinetics Using Single-Cell Transcriptomics.
The genome landscape: consequences of repetitive DNA organization and evolution in diploid and polyploid crops
R-loop coupled chromatin silencing at Arabidopsis FLC
How cells manage ribosome collisions
How epithelial cells polarise and why this goes wrong in cancer
A small RNA-based innate immune system guards the integrity of germ cell genomes
Specialization of the Drosophila nuclear export family protein, Nxf3, for piRNA precursor export
Structural studies of ribosome-associated quality and quantity control
The Flux Capacitor: How mitochondria shape the evolution of complexity
Condensation propensity of TDP-43 specifies the bound and regulated RNAs
Identifying and characterising RNA viruses in publicly available high throughput sequencing data
Centrosome amplification and cancer: reaching out
What drives the dependence of human germline mutation rates on sex, age, and time?
Transposable elements and the evolution of the human brain
A new force awakens: comparative approach to tissue morphogenesis in insects
Think Global Act Local: do local morphological changes influence differentiation of pluripotent cells?
Role of the endosomal network in cell and tissue organization
Deciphering the structure-function relationships of lncRNAs
Integrating protein, RNA and RBP localisation maps
Super-resolution imaging - STED and related advanced microscopy techniques
How like begets like: lessons from RNA silencing in C.elegans
Queuosine-modified tRNAs confer nutritional control of protein translation
Unearthing structure and complexity in human and great ape evolution
The Structure of Poly(A) Determines Deadenylation Specificity
Single cell full length cDNA library protocol with error correction
Cell cycle controls enforcing asymmetric spindle pole fate in budding yeast
Ancient genomic history and adaptation of human populations in Africa
Organoids and clonal analysis to study cell community interactions during pancreas development
SmRNA cap methylation and its role in transcription
Killing two viruses with one transposon: The doc transposable element mediates anti-viral function of genes
Hacking the gene expression machinery for genome defense
How to make or break an axon: the roles and regulation of neuronal microtubules
RNA modification detection and functional analysis by mass spectrometry and deep sequencing
SLAMseq: Thiol-linked alkylation for the metabolic sequencing of RNA
How evolution of mt-rRNA drives transformation of mitoribosomes
The structural plasticity of the Zika virus genome in human cells
Centriole Duplication: from body coordination in flies to skin cell biology and cancer
Versatility and dynamics of transcriptional responses to Notch
Characterisation of primary RNA methylations and their role in cancer
Spatially resolved transcriptomics to probe 3D RNA organization
Control of gene expression and cell cycle progression by mRNA nuclear sequestration
Cerebral organoids: modelling human brain development and tumorigenesis in stem cell derived 3D culture
Combining tools and technologies to identify post-transcriptional modifications in RNA
Viral evolution on sub-phylogenetic timescales
Scaling of tissue proportions to body size during vertebrate development
Environmental stress, cryptic variation and innovation in the simplest molecular systems
Quantitative HCR for RNA FISHing- Have you heard of it yet
Cryo-EM shows mechanism of 3' splice site selection
Conscious coupling: DEPS-1 links PIWI to endo-siRNA production in C. elegans
Rfam 13.0: The genome-centric sequence database
The Translational Response to Amino Acid Starvation in S. Pombe
Functional dissection of 3'UTR and RNA cis-regulatory elements by CRISPR-Cas9 genome engineering
An Editor’s Guide to Effective Science Communication
Capturing human axial progenitors in vitro
The evolution of meiosis and meiotic recombination in Arabidopsis arenosa.
Formation and disease relevance of axonal endoplasmic reticulum, a "neuron within a neuron”.
Visualize gene expression and genetic variants in the central and peripheral nervous systems with the RNAscope technology
piRNA-mediated regulation of transposon alternative splicing in soma and germline
Cheating in Pseudomnas aeruginosa drives switch to privatisation of an essential function
MicroRNAs and other regulatory RNAs
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Coordination of spindle positioning and cell cycle progression in yeast
Feedback cross-regulation between TDP-43 and paraspeckles promotes efficient exit from plutipotency
Common genetic variation drives molecular heterogeneity in human iPSCs
Post-transcriptional mechanisms that time development
Major glial changes in the human aging brain: from RNA to cells
Understanding the causes of variation in nucleotide diversity across the genome
Rate and pattern of evolutionary change in the gut microbiota as revealed by a commensal bacteria
Evidence for miRNA-mediated transcriptome regulation in the parasitic flatworm Schistosoma mansoni
Sperm Mediated Transgenerational Inheritance
Comparative population genomics in animals: genetic diversity, adaptive rate, species barrier
Predicting the pleiotropic effects of circadian timing, from clock gene expression to biomass.
The evolution of arthropod small RNA pathways
Evaluation of Lexogen Quantseq for gene expression profiling of novel compounds in drug discovery
Targeted polyA tail removal by the Ccr4-Not complex
NGS techniques for challenging RNA sample types
Using experimental evolution to understand adaptation from standing genetic variation.
Structure of the catalytic spliceosome
A transmissible RNA pathway in honey bees
Directing and shaping the inside-out axis of the vertebrate brain
Towards a complete view of the genetics of gene expression variation in yeast
Ptbp1 post-transcriptional action is essential for the formation of germinal centre B cells and the generation of high affinity antibodies.
New SHAPEs of retroviral RNAs
SMall RNAs control transposons during demethylation in mouse ES cells.
‘Uncovering new “lnc's” in mitosis : an RNA perspective.’
‘Cell types in the mouse brain as revealed by single-cell RNA-seq.’
Beyond the reference genome: inference using prior knowledge of the diversity of a species.
Genome diversity and evolution of DNA methylation genome in the human genome.
Modified RNA and grammer education for the naive immune system
Role of long noncoding RNAs in hematopoiesis
Selective control of genome maintenance pathways by RNA processing factors
Introduction to RNAcentral, a non-coding RNA sequence database
Role of neuromesodermal progenitors in axial elongation.
Checkpoint and non-checkpoint functions of Drosophila Mad1 and RZZ.
CryoEM structure of the spliceosomal U4/U6.U5 tri-snRNP at 3.7 Angstrom resolution.
Single cell RNA-sequencing reveals a continuous spectrum of differentiation in haematopoietic cells.
CrPV-IRES: the dynamic tale of a molecular pirate
Genomics approaches for the investigation of gene regulation.
Breaking the silence: defense and counter-defense in antiviral RNA silencing pathways of insects.
Transcriptional regulation and downstream program of Hox and Cdx genes during axial development in the mouse embryo.
MiRNA-containing gene regulatory networks in development
SIRVs – External Spike-in Transcript Variant Controls for RNA-Seq
Intra-tumour heterogeneity and genomic rearrangements in solid cancers.
Into the void: bridging the gap between risk genes and psychiatric phenotypes.
Mechanism and Regulation of miRNA-mediated Repression in Mammalian Cells including Retinal Photoreceptors
Novel insights into substrate recognition and targeting of mRNA to nonsense-mediated decay
LNA GapmeRs represent a powerful alternative for knocking down mRNAs and lncRNAs.
Codon usage determines mRNA levels in Trypanosoma brucei.
Inhibitory activities of short linear motifs underlie Hox interactome specificity in vivo.
Single-cell dynamics of the proliferation-quiescence decision.
How do miRNAs work?
Small RNAs mediate trans-generational epigenetic inheritance in C. elegans
Post-transcriptional RNA processing in the remnant chloroplast of the malaria parasite Plasmodium
Rapid microbial evolution: From the lab to the clinic and back again.
“The Nuclear Matrix Protein Matrin3 Regulates Splicing and Forms Overlapping Networks with PTB”
How dynein and its co-factors at the kinetochore ensure chromosome segregation fidelity.
Beyond cancer genetics: dissecting the transcriptional and epigenetic regulation in leukaemia.
Mitotic kinases and phosphatases work together to shape the right response.
Chemical and proteomic analysis of spliceosomes and multi protein complexes
Annotation and identification of potentially functional lncRNAs
Using zebrafish models to identify novel alleles affecting human behaviour- a proof of principle study using smoking as an example.
Decipher the RNA structural code: A transformative platform reveals novel regulatory features.
Investigating the consequences of age-linked gene expression changes
COMT: from single nucleotide polymorphism to whole brain function.
Large scale genomic analyses of complex traits in human populations.
Regulation of Notch signalling by the endosomal pathway.
Targeted Sequencing Reveals The Genome’s Fine Details
Structure of Prp8 and its implications for the spliceosomal active site
Organisation and Regulation of DNA supercoiling domains in Mammalian Chromatin.
C. elegans development: getting the seams right and living a balanced life.
The impact of viral IκB-like ANK proteins on host-parasitoid interactions.
‘Computational analysis of small RNA function in animals.’
Regulation of microRNA expression during virus infection.
Shaping and reshaping regulatory loops in Drosophila morphogen signaling.
Molecular mechanisms of Mediator complex recruitment by transcription factors.
"The end of the message: Insights into mRNA deadenylation"
Directional, amplification-free RNA-seq in for AT-rich malaria parasites
Computational insights into stem cell differentiation using dynamic hybrid modelling.
'Towards the RNA structure of everything'
'Small RNA biogenesis in the germline of C. elegans'
Targets of T cell responses against malaria liver infection: immunology meets experimental genetics.
A Drosophila resource to study human pathology.
Molecular insights into the ecology, epidemiology and evolution of bat rabies.
Vaccinia virus has evolved the Bcl-2 family of proteins to thwart the host innate immune system.
"Structure-function analysis of non-coding human Y RNA"
"Replicating RNA with RNA"
Checks and Balances in Drosophila Muscle and Heart Differentiation Programs.
Structural insights into the molecular mechanisms of accurate chromosome segregation.
Widespread translation of small Open Reading Frames from coding regions, UTRs and non-coding RNAs.
Cellular functions of intergenic lncRNAs
The evolution of the RNAi pathway and RNA viruses in Drosophila
The dynamics of Dengue virus transmission in nature
How does the kinetochore orchestrate a functional checkpoint signal?
Sibling Rivalry and Stress Tolerance: the Single-Cell Biology of Mycobacteria.
The evolutionary dynamics of unusual reproductive systems.
Tracking transmission and evolution of bacterial pathogens with high-throughput genomics.
How to maintain a stable genome: A Passenger Perspective.
Regulation of Muscle Stem Cell Fate
Cell specification in the mouse blastocyst inner cell mass: interplay between Nanog, Gata6 and the Fgf signalling pathway.
The mitotic checkpoint - a structural perspective.
Quantification and modeling of spindle positioning and size regulation in the C. elegans embryo
Hox Control of a Drosophila Feeding Circuit.
Perspectives on Next Generation DNA Sequencing.
Mechanisms of Transcriptional Repression during Development.
PTEN phosphatase-independent maintenance of apical membrane integrity during colorectal glandular morphogenesis.
A life in science: from academia to industry and back.
Phase-shifted gene-activity oscillations during embryo development - a real-time imaging approach.
Kick Off Meeting of the Cambridge RNA Club
Please see above for contact details for this list.
![[Talks.cam]](/static/images/talkslogosmall.gif)

Guillermo Parada Gonzalez (Postdoc, Crick Institute and KCL, London, UK), Eleni Liapi (Postdoc, Aarhus University, DK).
Thursday 26 March 2026, 16:30-18:30